中医药信息2011，Vol.28Issue(5)：58-61,4.
麦冬注射液对实验性大鼠腹膜透析并发腹膜炎的影响
The Effect of Ophiopogon Injection on Experimental Rats with Peritoneal Dialysis Complicated with Peritonitis
摘要
Abstract
Objective;To investigate the effect of routine dialysate( RD) added with Ophiopogon Injection on rats with peritoneal dialysis complicated with peritonitis and to study its defense mechansim. Methods; Forty clean SD rats were allocated to four groups: RD added with ophiopogon injection model group ( GroupA) , RD in model group (Group B) , ophiopogon injection in normal group ( Group C) and RD in normal group ( Group D). Rat models with peritonitis were established by intraperitoneal injection of Bacillus coli. The treatment course lasted 7 days. The mental state, appetite, urine and stool, and symptoms such as chill and restlessness were observed. After dialysis, routine examination and bacterial culture of peritoneal dialysate were carried out. The function of macrophyge in abdominal cavity was detected. Results: The number of white blood cell and neutrophil in dialysate were much lower in Group A, Group C and GroupD than those in Group B ( P < 0. 05 or P <0. 01). While the differences among Group A, Group C and Group D were not significant. No significant difference of protein concentration was found among the four groups ( P > 0. 05 ). Percentage of phygocytosis and phygocytic index of macrophyge were lower in Group B than those in Group A, Group C and Group D (P <0. 05 or P <0. 01). Percentage of phygocytosis was higher in Group C than that in Group D. While the difference phygocytic index between the two groups was not significant. Conclusion: RD added with ophiopogon injection can improve peritoneal dialysis complicated with peritonitis. Its mechanism may be related to the regulation of immune function and the increase of phygocytosis of macrophyge and defense function in abdominal cavity. No obvious stimulation is found in the study.关键词
腹膜炎/预防和控制/中药疗法/腹膜透析/副作用Key words
Peritonitis/Prevention and control/ Peritonitis/Chinese medicine therapy/ Peritoneal dialysis/side effect分类
医药卫生引用本文复制引用
王秀梅,姚菲菲,孙立秋,崔蕊,王莉..麦冬注射液对实验性大鼠腹膜透析并发腹膜炎的影响[J].中医药信息,2011,28(5):58-61,4.基金项目
黑龙江省自然科学基金项目(D200852) （D200852）
