中国组织工程研究与临床康复2011，Vol.15Issue(41)：7607-7610,4.DOI:10.3969/j.issn.1673-8225.2011.41.002
去卵巢牙周炎模型大鼠牙槽骨吸收与补骨脂的干预
Effects of psoralea corylifolia on alveolar bone absorption in an ovariectimized rat model of periodontitis
摘要
Abstract
BACKGROUND: Psoralea corylifolia exhibits obvious therapeutic effects on osteoporosis. OBJECTIVE: To investigate the effects of psoralea corylifolia on alveolar bone metabolism, alveolar bone mineral density and height in ovariectimized rats with periodontitis. METHODS: Thirty female Wister rats were randomly divided into three groups: ovariectomy, psoralea corylifolia and sham-surgery. Rats from the ovariectomy and psoralea corylifolia groups underwent bilateral ovariectomy, and rats from the sham surgery group did not receive ovariectomy. At 2 days after ovariectomy, rats from the psoralea corylifolia group were orally administered 3 g/kg psoralea corylifolia, once a day. At 2 weeks after ovariectomy, all rats were established into peridontitis models by ligation of maxillary molar. RESULTS AND CONCLUSION: At 12 weeks after ligation of maxillary molar, compared with sham surgery group, estradiol and calcium ion levels were significantly decreased (P < 0.05), alkaline phosphatase level was significantly increased (P < 0.05) in the ovariectomy group. X-ray and hematoxylin-eosin staining showed that alveolar bone mineral density and height in the ovariectomy group was significantly decreased than that in the control group (P < 0.05). Compared with ovariectomy group, serum level of calcium ion was significantly increased (P < 0.05) and alkaline phosphatase level was significantly decreased (P < 0.05), and alveolar bone mineral density and height were significantly increased in the psoralea corylifolia group. However, no significant difference was observed between psoralea corylifolia group and sham surgery group (P > 0.05). These findings suggest that estrogen-deficient state can promote alveolar bone absorption in rats with experimental periodontitis, and psoralea corylifolia can prevent the decrease in alveolar bone height and density resulting from estrogen deficiency.关键词
补骨脂/雌激素/牙周炎/牙槽骨/骨质疏松分类
医药卫生引用本文复制引用
朱建华,迟玉红,张艳秋,刘继光..去卵巢牙周炎模型大鼠牙槽骨吸收与补骨脂的干预[J].中国组织工程研究与临床康复,2011,15(41):7607-7610,4.基金项目
教育部科学技术研究项目(205041),课题名称:PTHrP对牙胚发生作用机制的研究. （205041）
