中国临床药理学与治疗学2011，Vol.16Issue(9)：1016-1020,5.
阿立哌唑与奥氮平对首发精神分裂症 急性期疗效及对催乳素的影响
Therapeutic effects of aripiprazole and olanzapine on the patients with first-episode acute schizophrenia and their influence on plasma prolactin level
摘要
Abstract
AIM:To study the efficacy on first-episode acute schizophrenia treated with aripiprazole and olanzapine and the effect on plasma prolactin level. METHODS: 65 inpatients with first-episode acute schizophrenia were divided into either olanzapine group [n = 42, M21, F21; age(23. 9±6. 6)year] or aripiprazole group[(n=23, M1l, F12; age (23. 7 ± 7. 2) year] for 4 week treatment. The plasma prolactin level, the Positive and Negative Syndrome Scale (PANSS) and clinical global impressionglobal improvement (CGI-I) were measured before and after 4 week treatment. RESULTS: The score of PANSS (59 ± 13) after therapy in olanzapine group was significantly lower than that before therapy (103+15) (P<0.01). The score of PANSS (60 ±18) after therapy in aripiprazole group was significantly lower than that before therapy < 101 ± 13) (P<0.01). After therapy, there was no significant difference(P> 0.05) in the CGI-I score between the two groups. The difference of negative symptoms and general psychopathological sub-scale scoreschanging from base to end between the two groups was statistically significant (P<0. 01). Compared with the prolactin baseline level (547 ±382) uIu/mL,the plasma prolactin level (418 ±362) ulu/mL in olanzapine group was significantly decreased after treatment, and there was no difference. Compared with the prolactin baseline level (351 ±299) ulu/mL, the plasma prolactin level (123 ±114) ulu/mL in aripiprazole group was significantly decreased after treatment, and there was significant difference ( P < 0.01). CONCLUSION: The therapeutic effects were similar in the aripiprazole and olanzapine group for first-episode acute schizophrenia. Olanzapine is better for the general psychopathological symptoms, and aripiprazole is better for the negative symptoms. Aripiprazole maybe decrease the plasma prolactin level of first-episode acute schizophrenia.关键词
阿立哌唑/奥氮平/首发精神分裂症/催乳素Key words
Aripiprazole/ Olanzapine/ Firstepisode schizophrenia/ Prolactin分类
医药卫生引用本文复制引用
吴小立,王继辉,钟智勇,韩自力..阿立哌唑与奥氮平对首发精神分裂症 急性期疗效及对催乳素的影响[J].中国临床药理学与治疗学,2011,16(9):1016-1020,5.基金项目
广东省科技计划非典型抗精神病药物所致血脂异常的分子机制探讨(2009B080701080) （2009B080701080）
