中国临床药理学与治疗学2011，Vol.16Issue(9)：1033-1038,6.
早卵泡期促性腺激素释放激素激动剂降调节联合人绝经期促性腺激素在卵巢储备功能低下者促排卵中应用
Clinical application of Gonadotropin-release hormone agonist (GnRHa) down-regulation in early follicle phase combined with ovarian stimulation by human menopausal gonadotropin (HMG) protocol for patients who have decreased ovarian reserve
余蓉 1赵军招 1肖仕全 1王佩玉 1林佳 1杨海燕1
作者信息
- 1. 温州医学院附属第一医院生殖中心,温州325000,浙江
- 折叠
摘要
Abstract
AIM:To investigate the effect of the GnRH-a down-regulation in early follicle phase combined with ovarian stimulation by HMG protocol for patients who have decreased ovarian reserve. METHODS: Clinical retrospective analysis was performed on 109 cycles in total 109 patients received IVF or ICSI treatment between May 2010 and March 2011. The 109 cycles were divided into three groups by stimulation protocol. Group A consisted of cycles with GnRH-a down-regulation protocol. Group B consisted of cycles with mild stimulation protocol. Group C consisted of cycles with GnRH-a flare-up protocol. The clinical and laboratory outcome of three groups were compared. RESULTS: The gonadotropin used in Group B was significantly less than that of Group A and C(P <0. 01). The serum level of LH in Group A was significantly lower than that of Group B and C( P < 0. 01). Group C showed a significant higher level of E2 compared with Group A and B (P<0. 01). No significant difference was observed in the number of oocytes retrieved and the rate of maturation and fertilization ( P >0. 05). There was no significant difference in the clinical pregnancy rate per transfer in three groups (33. 33% vs 32.35% vs 36.00%, P> 0. 05). The cancel rate was significantly higher in Group B (34. 62%) when compared with Group A (11. Ll%)(P = 0.02), but the difference was not significant when it was compared with Group C (16. 67%) (P = 0. 05). The first-trimester abortion rate of Group C (33.33%) was significantly higher than that of Group A (12.50%, P = 0. 028) and Group B (18. 18%,P = 0.03). CONCLUSION: GnRH-a down-regulation in early follicle phase combined with HMG protocol could reach a comparable pregnancy rate as mild stimulation protocol and GnRH-a flare-up protocol for patient with decreased ovarian reserve. Furthermore, the cancel rate and the first-trimester abortion rate could be decreased.关键词
促性腺激素释放激素激动剂/人绝经期促性腺激素/卵巢储备Key words
Gonadotropin-releasing hormone agonist:Human menopausal gonadotrophin/ Ovarian reserve分类
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余蓉,赵军招,肖仕全,王佩玉,林佳,杨海燕..早卵泡期促性腺激素释放激素激动剂降调节联合人绝经期促性腺激素在卵巢储备功能低下者促排卵中应用[J].中国临床药理学与治疗学,2011,16(9):1033-1038,6.
