摘要
Abstract
AIM: To observe the safety and the appropriate amount of sedation of dexmedetomidine on the recovery period after general anesthesia. METHODS: Sixty patients undergoing abdominal gynecological surgery after general anesthesia, aged 40-55 yrs, weight 50 -75 kg, the operation time between 1-2.5 h. Patients were induced and maintained according to the same kilogram of body weight, then sent into the recovery room after surgery. They were randomly divided into four groups: Saline control group, D1 group: dexmedetomidine group 0.2 μg/kg, D2 Group: dexmedetomidine group 0.4 jug/kg, D3 Group: dexmedetomidine group 0. 6 fig/kg. The blood pressure, heart rate, respiration rate, pulse oxygen saturation and Ramsay sedation scores were monitored before ( T1 ) and after using the drugs 5 min (T2 ), 30 min (T3), before(T4) and after tracheal extubation (T5), and leaving room(T6). Blood gas was recorded before(T1) and after using the drugs 30 min(T3), and leaving room(T6). Time of extu-bation and leaving room, then sleep, bradycardia, hypotension and other side effects were observed. RESULTS: Compared with before administration, the blood pressure and heart rate decreased in the three groups after administration (P<0. 05). The blood pressure and heart rate in D2 Group and D3 Group were lower than the other groups at T2, T4-T6 (P<0. 05). RS in NS Group and D, Group were higher than D2 Group and D3 Group (P<0. 05). OAAS and BIS in D3 Group were lower than other groups. Ramsay sedation scores in D3 Group were higher than the other groups (P<0. 05). D3 Group had the higher risk back to sleep and bradycardia (P <0. 05). CONCLUSION: It is safe that DEX is used in patients with sedation during the recovery period after general anesthesia. It improves the quality of awakening.关键词
右美托咪啶/苏醒期/镇静Key words
Dexmedetomidine/ Recovery period/Sedation分类
医药卫生
