南京医科大学学报（自然科学版）2011，Vol.31Issue(10)：1451-1454,1470,5.
初发2型糖尿病患者血清25-羟维生素D水平及相关性研究
Blood serum level of 25-hydroxy-vitamin D in initial type 2 diabetes mellitus
摘要
Abstract
Objective; To explore the role of vitamin D in the pathogenesis of initial type2 diabetes mellitus (T2DM) by comparing the difference of blood serum 25-hydroxy-vitamin D[25(OH)D],clinical and biochemical indexes between initial T2DM and normal persons. Methods: Sixty-five patients with T2DM were enrolled and divided into T2DM A group and T2DM B group according to the level of serum 25 (OH)D, and 32 healthy people were selected as control. The levels of serum 25 (OH)D,clinical and biochemical indexes were compared between two groups, and the difference of relative indexes including waistline,BMI,SBP,DBP,FBS,HbAlC, PTH were compared. Results: The level of serum 25 (OH)D in the case group was significantly lower than that in the control group. Serum 25(OH)D was nagetively related to BMI,TG,Apo-Al and PTH,and was positively related to HDL-C. There was no relationship between hypovitaminosis D and blood pressure,glucose or HbAlC. Conclusion; The level of serum 25 (OH)D in the patients with initial T2DM was low,especially with obesity and abnormality in blood-fat. There was no relationship between serum 25(OH)D and blood pressure,glucose, calcium or glycosylated hemoglobin. The reason that T2DM patients were easily complicated by hypertension was possibly related to the rise of PTH, and the mechanism is expected to study.关键词
初发2型糖尿病/维生素D/25羟维生素D/糖化血红蛋白/甲状旁腺激素Key words
initial type 2 diabetes mellitus:vitamin D:25-hydroxv-vitamin D-.elycosvlated hemoglobin:parathyroid hormone分类
医药卫生引用本文复制引用
丁怡,丁国宪,钱珂,唐暎,汪心水,张俊,刘息平..初发2型糖尿病患者血清25-羟维生素D水平及相关性研究[J].南京医科大学学报（自然科学版）,2011,31(10):1451-1454,1470,5.基金项目
基金项目南京医科大学第一附属医院创新团队面上项目(代谢与衰老研究) （代谢与衰老研究）
