河南农业大学学报2011，Vol.45Issue(3)：323-327,5.
非扫描式光学SPR生物传感器的数据分析
Data analyses of a non-scanning optical biosensor based on surface plasmon resonance
摘要
Abstract
This paper proposes a novel design method of optical surface plasmon resonance biosensor in which a laser linear generator was used as a light source of the bioanalyzer, suggesting under appropriate assumptions, an optimal analysis fitting method derived for measuring biomolecular interaction parameters, and a centroid arithmetic for calculating the resonance dip position of a reflected spectra for an decrease in signal to noise ratio. A series of experiments were designed to validate the performance of the optical biosensor using different volume fraction ethanol. In a certain range of volume fraction ethanol, we process the data by polynomial fit and conclude that there is a linear relationchip between the concentration of ethanol and optical response dip of optical SPR. The correlation coefficient is -0.985 2 and sensitivity is 959. 60(resonance pixels position per volume fraction ethanol), suggesting that the fitting algorithm is insensitive to optical power and surrounded factors correlated noise/ drift.关键词
表面等离子共振/生物传感器/非扫描/多项式拟合/质心法Key words
surface plasmon resonance/ biosensor/ non-scanning/ polynomial fit/ centroid method分类
通用工业技术引用本文复制引用
赵媛媛,肖龙,朱莺,胡建东,江敏,胡枫江,魏文松,李会芹..非扫描式光学SPR生物传感器的数据分析[J].河南农业大学学报,2011,45(3):323-327,5.基金项目
河南省教育厅创新人才项目(2009HASTIT019) （2009HASTIT019）
河南省杰出青年基金项目(104100510017) （104100510017）
郑州市科技领军人才项目(096SYJH25 101) （096SYJH25 101）
