南方医科大学学报2011，Vol.31Issue(10)：1693-1696,4.DOI:44-1627/R.20111004.1050.004
肿瘤浸润性树突状细胞在子宫内膜癌中的凋亡及其Fas、FasL表达意义
Apoptosis and expression of Fas/FasL in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma
摘要
Abstract
Objective To investigate apoptosis of tumor infiltrating dendritic cells (TIDC) and their expression of Fas/ FasL (CD95/CD95L) in human endometrioid adenocarcinoma. Methods The apoptotic rate of TIDC was measured in 45 cases of endometrioid adenocarcinoma and 20 cases of normal endometrium tissues (control) by double-label immunohistochemistry using the monoclonal antibody S-100 protein and TUNEL technique. The expressions of Fas and FasL in TIDCs were detected using double-label immunohistochemistry and imaging analysis. Results The apoptotic rate of TIDCs in endometrioid adenocarcinoma were significantly higher than that in normal endormetrium [(13.02±0.64)% vs (6.82±0.53)%, P＜0.05]. The expression levels of Fas in the TIDCs were significantly lower, whereas FasL expression significantly higher in endometrioid adenocarcinoma than in normal endormetrium (7.88 ±1.05 vs 19.25 ±3.03, P＜0.05; 12.95 ±2.25 vs 7.51 ±1.14, P＜0.05). Conclusion Increased apoptosis of the TIDCs and abnormal expression of Fas/FasL in TIDCs in endometrioid adenocarcinoma may lead to tumor immune escape.关键词
子宫内膜癌/肿瘤浸润性树突状细胞/凋亡/Fas/FasLKey words
endometrioid adenocarcinoma/ tumor infiltrating dendritic cell/ apoptosis/ Fas/ FasL分类
医药卫生引用本文复制引用
贾建军,王自能,刘革修,王志新..肿瘤浸润性树突状细胞在子宫内膜癌中的凋亡及其Fas、FasL表达意义[J].南方医科大学学报,2011,31(10):1693-1696,4.基金项目
国家自然科学基金(30670902) （30670902）
广东省医学科学技术研究基金(A2009361) （A2009361）
