摘要
Abstract
[Objective] To investigate the value of video-assisted thoracoscopic surgery (VATS) in the treatment of nonthymomatous myasthenia gravis (NTMG) by comparing the medium-term efficacy and quality of life after extensive thymectomy of VATS and median sternotomy. [Methods] A retrospective analysis on 52 cases of NTMG, who were preoperatively confirmed to be NTMG from May 2003 to June 2006 were divided into VATS group (26 cases) and conventional thoracotomy group (26 cases); Clinical efficacy was measured by DeFlippi class for changes in myasthenia gravis-associated symptoms and MGFA score, quality of life was studied by modified the European Organization for Research and Treatment of Cancer (EORTC) quality-of-life questionnaire (QLQ) at 3-years of the follow-up. [ Results ] 1 cases occurred muscle weakness crises in open-chest group, but none in VATS group. At 3-years of the follow-up, symptoms improved of patients with VATS better than open-chest group (P <0.05), and the VATS group was higher than chest group in MGFA score (P <0.05), total effectiveness with VATS group and open-chest group were 100% (26/26) and 80.8%(21/26), and statistics in two groups was not significant (P >0.05), six item score of EORTC-QLQ (Physical, Role, Cognitive, Emotional, Social, Global ability) of VATS group is superior over conventional group (P >0.05). [Conclusions] VATS thymectomy can be regarded as the treatment of choice for patients undergoing surgery for nonthymomatous myasthenia gravis, it will has a wonderful applied future of clinic.关键词
电视胸腔镜手术/胸腺扩大切除/重症肌无力/生活质量Key words
video-assisted thoracoscopic surgery/ extended thymectomy/ myasthenia gravis/ quality of life分类
医药卫生
