临床与实验病理学杂志2011，Vol.27Issue(11)：1165-1168,4.
胃癌组织中Twist、HIF-1α表达与上皮间质转化的关系
Expression of Twist and HIF-1α in gastric carcinoma and their relationship with epithelial-mesenchymal transition
摘要
Abstract
Purpose To investigate the relationship between the expressions of Twist, HIF-1 a and clinical pathological parameters in gastric carcinoma. Explore its significance in judging the prognosis of patients. Analyze the expression of two proteins in the epithelial-mesenchymal transition phenomenon. Methods Immuohistochemistry was used to detect the expressions of Twist and HIF-lα in 120 cases of gastric carcinoma specimens and corresponding adjacent normal tissue. Results In gastric carcinoma Twist, HIF-1α., N-cad, E-cad positive rate was 59. 1% , 61. 7% , 46. 7% , 37. 5% , adjacent tissues, the positive rate was 18. 3% , 22. 5 % , 10. 8% , 91. 7%. Tumor tissues and adjacent tissues there were significant differences ( P < 0. 05 ). Patients with Twist positive expression showed higher incidence of lymph node metastasis ( P < 0. 05 ) and distant metastasis ( P < 0. 05 ) than those with Twist negative expression. HIF-1α expression was closely correlated with tumor histological type, depth of invasion, lymph node metastasis( P <0. 05 ). Patients with high expression of Twist and ( or ) HIF-1α had lower five-year survival rate than patients with negative expression. The expression of Twist and HIF-1α was significantly correlated in gastric carcinoma accompanied by low expression of E-cad and abnormal high N-cad expression ( P < 0. 05 ). Conclusions The expression of Twist and HIF-1α was closely related to the biological characteristics in gastric carcinoma, detection the expression of Twist and HIF-1α was valuable in predicting tumor prognosis, invasion and metastasis. HIF-1α promoted the phenomenon of epithelial mesenchymal transition may be by upregulating the Twist' s expression.关键词
胃肿瘤/上皮间质转化/Twist/HIF-1α/转移Key words
gastric neoplasms/epithelial-mesenchymal transition/Twist/HIF-1α/metastasis分类
医药卫生引用本文复制引用
张佐阳,邹萍,吴继锋..胃癌组织中Twist、HIF-1α表达与上皮间质转化的关系[J].临床与实验病理学杂志,2011,27(11):1165-1168,4.基金项目
安徽医科大学校科研基金(0117011201) （0117011201）
