南方医科大学学报2011，Vol.31Issue(10)：1753-1756,1777,5.DOI:44-1627/R.20111004.1054.005
8种环境内分泌干扰物对多囊卵巢综合征胰岛素抵抗的影响
Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: a preliminary investigation
摘要
Abstract
Objective To investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods This study was conducted among 60 patients with PCOS, including 23 with insulin resistance (PCOS-IR) and 37 without insulin resistance (PCOS-NIR), and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder (control group). The serum levels of 6 phthalic acid esters (PEAs), bisphenol A (BPA) and octylphenol (OP) were measured in all the subjects. Results The levels of PAEs, BPA and OP showed no significant differences between PCOS patients and the control group (P＞0.05). The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR (47.89 ng/ml vs 60.24 ng/ml, P＜0.05). Conclusion PEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance, but OP may play a role in insulin resistance in PCOS patients.关键词
环境内分泌干扰物/多囊卵巢综合征/胰岛素抵抗/双酚A/辛基酚/邻苯二甲酸酯Key words
environmental endocrine disruptors/ polycystic ovary syndrome/ insulin resistance/ bisphenol A/ octylphenol/ phthalic acid esters分类
医药卫生引用本文复制引用
李婷婷,邱东升,韩代文,胡蓉,许良智,陈永亨,邓红梅,梁春营,刘颖,刘晓芳,张静,康德英..8种环境内分泌干扰物对多囊卵巢综合征胰岛素抵抗的影响[J].南方医科大学学报,2011,31(10):1753-1756,1777,5.基金项目
四川省卫生厅科学研究项目(100377 （）
060020 （）
090289) （）
