南方医科大学学报2011，Vol.31Issue(10)：1761-1763,3.DOI:44-1627/R.20111010.1757.003
贝那普利和缬沙坦对高血压病患者促红细胞生成素水平的影响
Effects of benazepril and valsartan on erythropoietin levels in patients with essential hypertension
摘要
Abstract
Objective To compare effects of valsartan and benazepril on erythropoietin (EPO) levels in essential hypertensive patients with normal renal function. Methods Sixty essential hypertensive patients were randomly divided into valsartan group (n=30, valsartan 80 mg/day) and benazepril group (n=30, benazepril 10 mg/day). Plasma EPO and hemoglobin (Hb) levels were measured at the start of and at 4 and 8 weeks during the treatments. Results EPO and Hb levels were all in normal range in the two groups. Valsartan decreased EPO levels from 14.179±3.214 U/L (baseline) to 12.138+2.926 U/L (P＜0.05) and Hb levels from 144.32±13.84 g/L (baseline) to 135.16±14.78 U/L (P＜0.05). Benazepril treatment did not resulted in any obvious changes in EPO or Hb levels (P＞0.05). Conclusion Valsartan may lower EPO and Hb levels in patients with essential hypertension, while benazepril does not have such effects. The safety of valsartan in anemic hypertensive patients should be further investigated.关键词
高血压病/缬沙坦/贝那普利/促红细胞生成素Key words
essential hypertension/ valsartan/ benazepril/ erythropoietin分类
医药卫生引用本文复制引用
郭琳琳,李敏,王爱红..贝那普利和缬沙坦对高血压病患者促红细胞生成素水平的影响[J].南方医科大学学报,2011,31(10):1761-1763,3.基金项目
山东省自然科学基金(2010ZRB 14888) （2010ZRB 14888）
