南方医科大学学报2011，Vol.31Issue(10)：1781-1783,3.DOI:44-1627/R.20111004.1633.024
Src羧基端激酶结合蛋白在食管癌中的表达及其临床意义
Expression of Csk-binding protein in esophageal carcinoma and its possible implications
摘要
Abstract
Objective To investigate the expression of Csk-binding protein (CBP) in esophageal carcinoma and its association with the tumorigenesis and progression of esophageal cancer. Methods RT-PCR and Western blotting were employed to determine the expressions of CBP at the mRNA and protein levels in 50 pairs of fresh esophageal carcinoma tissue and the adjacent normal tissues. Results CBP mRNA and protein expressions in normal tissues were 1.43- and 1.28-fold higher than those in the cancer tissues, respectively (P＜0.05). The expressions of CBP mRNA and protein were positively correlated (P=0.015). The decreased expressions of CBP were significantly correlated to lymph node metastasis of esophageal cancer (P＜0.05). Conclusion The expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression of this malignancy.关键词
食管癌/Src羧基端激酶/Src羧基端激酶结合蛋白/肿瘤转移Key words
esophageal carcinoma/ C-terminal Src kinase/ Csk-binding protein/ metastasis分类
医药卫生引用本文复制引用
周栋,张安平,刘涛,李志勇,杨永珠,宋润泽..Src羧基端激酶结合蛋白在食管癌中的表达及其临床意义[J].南方医科大学学报,2011,31(10):1781-1783,3.基金项目
中央高校基本科研业务费专项资金自由探索项目(lzujbky-2009-1 51) （lzujbky-2009-1 51）
兰州大学中央高校基本科研业务费专项资金(lzujbky-2011-t03-16) （lzujbky-2011-t03-16）
