南方医科大学学报2011，Vol.31Issue(10)：1789-1791,3.DOI:44-1627/R.20111009.1608.001
瑞舒伐他汀对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗后存活心肌功能及动脉粥样硬化的影响
Rosuvastatin improves myocardial function and arteriosclerosis plaque in patients with ST-segment elevation after acute myocardial infarction and percutaneous coronary intervention
林泽鹏 1舒平春 1廖志坚 1王小庆 1刘强1
作者信息
- 1. 深圳市孙逸仙心血管医院心内科,广东深圳518020
- 折叠
摘要
Abstract
Objective To evaluate the effect of rosuvastatin on the functions of the surviving myocardium and arteriosclerosis plaque in patients with ST-segment elevation after acute myocardial infarction (STEMI) and percutaneous coronary intervention (PCI). Methods Sixty-five STEMI patients were randomized to receive 40 mg simvastatin (n=32) or 10 mg rosuvastatin (n=33) before sleep in addition to conventional medications. Before PCI and after the 12-month medications, the plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were measured, and echocardiography and 99TCm-MIBI single-photon emission computed tomography (SPECT) were performed to assess the therapeutic effects. Results At the end of 12 months, the patients in simvastatin group showed significantly reduced total cholesterol, LDL-C, CRP, TNF-a, and 99TCm-MIBI uptake fraction. In rosuvastatin group, these reductions were even more obvious; the intima media thickness (IMT) of the common carotid artery was reduced significantly after a 12-month rosuvastatin therapy, but almost remained unchanged after simvastatin therapy. Conclusion Rosuvastatin therapy in addition to conventional medications can significantly reduce IMT and improve the functions of the surviving myocardium in patients with STEMI after PCI.关键词
急性心肌梗死/瑞舒伐他汀/颈动脉内膜中层厚度/存活心肌Key words
acute myocardial infarction/ rosuvastatin/ intima media thickness/ myocardium分类
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林泽鹏,舒平春,廖志坚,王小庆,刘强..瑞舒伐他汀对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗后存活心肌功能及动脉粥样硬化的影响[J].南方医科大学学报,2011,31(10):1789-1791,3.
