中国实用妇科与产科杂志2011，Vol.27Issue(7)：526-529,4.
低危型妊娠滋养细胞肿瘤耐药高危因素探讨
Investigation the high-risk factors of drug resistance in low-risk gestational trophoblastic neoplasia
摘要
Abstract
Objective To investigate the related high-risk factors of drug resistance in low-risk gestational trophoblastic neoplasia(GTN). Methods 452 cases of low-risk GTN patients admitted in Women's Hospital of Zhejiang University between Jan 2000 and Jan 2010 were analyzed retrospectively. According to drug resistance or not, they are divided into drug resistant group(86 cases) and non-drug resistant group(366 cases). Results The incidence of drug resistance is 19. 03%. High serous hCG level before initial chemotherapy ( especially greater than 10 000 U/L) , lung metastases in several places, distant metastasis, large lesion in uterine are apt to develop drug resistance; Drug resistance happens in choriocarcinomas more easily than invasive hydatidiform moles; In addition, serious side effects of chemotherapy, insufficient course and dose of treatment for sensitive to chemotherapy drugs, long interval time between two courses are also prone to be resistant. However, there are no difference in age, clinical stages, previous pregnancy properties, chemotherapy drugs and the way to administration, interval time between last pregnancy and initial chemotherapy ( P > 0. 05). Conclusion Chemotherapy regimens should be individualized. Combined drugs should to be administered reasonably to high-risk group as early as possible. Also, we should pay attention to comprehensive treatment such as surgery. Only in this way, we can reduce the rate of drug resistance and improve the curative effect.关键词
低危型妊娠滋养细胞肿瘤/耐药/高危因素Key words
low-risk gestational trophoblastic neoplasia/ drug resistance/ high-risk factors分类
医药卫生引用本文复制引用
杨焯,钱建华..低危型妊娠滋养细胞肿瘤耐药高危因素探讨[J].中国实用妇科与产科杂志,2011,27(7):526-529,4.基金项目
浙江省自然科学基金资助项目(J20091445) （J20091445）
浙江省重大科技专项和优先主题项目(I20100055) （I20100055）
