中国实用妇科与产科杂志2011，Vol.27Issue(7)：538-540,3.
卵巢癌顺铂耐药细胞模型中14-3-3蛋白的差异表达
Differential expression of 14-3-3 proteins in platinum resistance ovarian cancer cell model
王慧香 1翟建军 1王蕾 1侯丽娟 1孙燕1
作者信息
- 1. 首都医科大学附属北京同仁医院妇产科,北京100176
- 折叠
摘要
Abstract
Objective To investigate the differential expression of 14-3-3 proteins in platinum resistance and platinum sensitive ovarian cancer cell clones. Methods The proteins of C0C1 and C0C1/DDP were separated by highly sensitive two-dimensional differential gel electrophoresis (2-D DIGE) coupled with Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF-MS) for the identification of protein differentially expressed in cisplatin sensitive and cisplatin resistance cell lines. Results We found a group of the distinct expressed proteins between C0C1 and C0C1/DDP. Among them, and 14-3-3￡were the up regulated proteins ( 14-3-3<r up regulated 31%. Student's Mest;P=0. 0049; 14-3-3ζ up regulated 38%. Student's t-test;P =0. 0032). Conclusions The differential expression of 14-3-3proteins in C0C1/ DDP lays foundation for the research of ovarian cancer platinum resistance, and offers new therapy targets for them.关键词
卵巢癌/耐药/14-3-3蛋白Key words
ovarian cancer/ drug resistance/ 14-3-3 proteins分类
医药卫生引用本文复制引用
王慧香,翟建军,王蕾,侯丽娟,孙燕..卵巢癌顺铂耐药细胞模型中14-3-3蛋白的差异表达 [J].中国实用妇科与产科杂志,2011,27(7):538-540,3.
