摘要
Abstract
Objective To investigate clinical or laboratory factors influence development of triploid (3PN) zygotes after intracytoplasmic sperm injection(ICSI) and pregnancy results. Methods A retrospective study of 287 ICSI cycles was carried out from the center of Reproductive Medicine of the second hospital of Hebei Medical University from January 2007 to December 2008. Cycles were divided into two groups; group A, cycles with one or more 3PN zygotes after ICSI, and group B, cycles with no 3PN zygotes. Age, amount of gonadotropin administered, peak estradiol levels, number of oocytes retrieved and injected, time between retrieval and injection, percentage of oocyte abnormal, sperm quality, percentage of diploid zygotes, and implantation rates, pregnancy rates,abortion rates and something else were compared between two groups. Results Compared with patients in group B, those in group A received significantly fewer ampoules of gonadotropins(28. 45 ±8. 68 vs 33. 66 ± 14. 02) , had higher estradiol levels( 10203. 04 ±3402. 97pmol/L vs 8649. 27 ± 3870. 19pmol/L) , and had more oocytes( 17. 09 ± 8. 58 vs 11. 34 ±6. 52) , and oocytes injected( 13. 61 ± 7. 49 vs 9. 26 ±5. 41) and lower percentages of diploid zygotes[ (66. 85 ± 18. 69)% vs (77. 39 ± 19. 31)% ]. However, implantation rates, pregnancy rates, abortion rates did not differ between two groups. Conclusion The abnomal quality or internal stucture of oocytes dued to high responders to ovarian may be a possible cause of 3PN zygotes after ICSI. But it is not associated with low pregnancy outcome and should not be completently explained by high responders to ovarian.关键词
卵胞浆内单精子显微注射/三倍体/原核/促性腺素Key words
ICSI/ triploidy/ pronuclei/gonadotropins分类
医药卫生
