中国实用内科杂志2011，Vol.31Issue(7)：533-535,3.
不同免疫状态下肺曲霉菌感染24例临床分析
Pulmonary aspergillosis: clinical analysis in immunocompetent and immunocompromised patients
彭敏 1蔡柏蔷 1施举红 1罗金梅 1王澎 2冯瑞娥 3肖毅 1许文兵 1朱元珏1
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院,呼吸内科,北京100730
- 2. 中国医学科学院北京协和医学院北京协和医院,检验科微生物室,北京100730
- 3. 中国医学科学院北京协和医学院北京协和医院,病理科,北京100730
- 折叠
摘要
Abstract
Objective To analyze the clinical characteristics and treatment of pulmonary aspergillosis in im-munocompetent and immunocompromised patients. Methods Patients diagnosed as proven pulmonary aspergillosis in Peking Union Medical College Hospital from Jan 2000 to Mar 2010 were included in this analysis. Clinical characteristics were studied retrospectively. Results 24 patients were included,7 immunocompetent and 17 immunocompromised patients. Fever was more common in immunocompromised patients than immunocompetent patients (88. 2% vs 28. 6% ,P <0. 05), While hemoptysis was more common in immunocompetent patients than in immunocompromised patients(71.4% vs 11.8% ,P <0.05). A single or localized lesion on CT scan was more common in immunocompetent patients than in immunocompromised patients(57. 1% vs 11. 8% ,P<0. 05). Surgical resection was performed in 5 (71% ) immunocompetent patients; While the immunocompromised patients received antifungal drug therapy except 1 patient. The prognosis of immunocompetent patients was better than immunocompromised patients. Severe complications, no improvement of immunocompromised factors and decreased lymphocyte may correlated with prognosis in immunocompromised patients. Conclusion The clinical manifestations and imaging findings of pulmonary aspergillosis was different in immunocompetent and immunocompromised patients. There were benign clinical course in immunocompetent patients. Treatment of pulmonary aspergillosis should be sorted according to their immune status.关键词
肺曲霉菌感染/免疫缺陷/免疫正常Key words
pulmonary aspergillosis/immunocompetent/immunocompromise分类
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彭敏,蔡柏蔷,施举红,罗金梅,王澎,冯瑞娥,肖毅,许文兵,朱元珏..不同免疫状态下肺曲霉菌感染24例临床分析[J].中国实用内科杂志,2011,31(7):533-535,3.
