中国实用内科杂志2011，Vol.31Issue(7)：539-541,3.
血液透析患者骨保护素细胞核因子κB受体活化因子配体与动脉僵硬度的关系
Relationship of OPG,sRANKL level and pulse wave velocity in maintenance hemodialysis patients
韦洮 1王梅 1王宓 1杨镜华 1李欣1
作者信息
- 1. 北京大学人民医院肾内科,北京100044
- 折叠
摘要
Abstract
Objective Aortic stiffness increases end-stage renal disease all-cause and cardiovascular mortality risks. We investigated arterial stiffness through the pulse wave velocity (PWV) and the roles of osteoprotegerin (OPG) and soluble receptor activator for NF-kB ligand (sRANKL) in hemodialysis patients. Methods In 40 hemodialysis patients,serum OPG/sRANKL levels and arterial stiffness were measured through ELJSA and Pulse Pen tonometry, respectively. The presence of vascular calcification were measured using plain radiographs. Results Compared with patients with slight degree vascular calcification,serum OPG levels[ (342. 50 ± 171. 53)ng/L vs (206.21 ±137.88)ng/L,t= -2.253.P =0.025]and OPG/s RANKL ratio (454.65 ±455.63 vs 135.31 ± 136. 81 ,t =59,P = 0.035) were significantly higher(P<0. 05),serum sRANKL levels[ (0.10 ±0. 08)pmol/L vs (0. 12 ±0.08) pmol/L,tT =0. 534] were not significantly different in patients with severe degree vascular calcification. Compared to controls, hemodialysis patients had higher carotid-femoral [( 9.48 ± 1.80)m/s vs (8.58 ± 1. 29)m/s,t =2.073] and carotid-radial[ (13.42 ±3. 26)m/9 vs (10.07 ± 1. 76)m/s,t =4. 836]PWV values. Serum OPG levels was significantly higher[ (235.12 ±154.33) ng/L vs ( 93. 00 ± 44.10) ng/L, t = 3.489,P = 0. 001 ] sRANKL was no significant in both groups [ (0. 12 ± 0.08) pmol/L vs (0. 16 ± 0.08) pmol/L, t = -1.410]. Soluble RANKL,phosphorous and product of calcium and phosphorous (or age) were independent deter-minants of carotid-radial (or carotid-femoral) PWV. Conclusion Arterial stiffness is increased in hemodialysis patients. Serum sRANKL is an independent risk factor of increased peripheral muscular-type arterial stiffness.关键词
血液透析/骨保护素/细胞核因子κB受体活化因子配体/脉搏波速度Key words
hemodialysis/osteoprotegerin/solube receptor activator of NF-kB ligand/pulse wave velocity分类
医药卫生引用本文复制引用
韦洮,王梅,王宓,杨镜华,李欣..血液透析患者骨保护素细胞核因子κB受体活化因子配体与动脉僵硬度的关系[J].中国实用内科杂志,2011,31(7):539-541,3.
