摘要
Abstract
BACKGROUND: Biological pacemakers need not replace battery, can approach magnetic field, and has automatic reaction to theneurotransmitter inside the body. It is an effective method to treat cardiac conduction system disease.OBJECTIVE: From gene treatment, cell transplantation, hormone curing to acquaint the methods of building biologicalpacemakers.METHODS: Using "biological pacemaker" as a keyword in Chinese and English, a computer-based search of Wanfang andPubMed databases (2000-03/2009-03) was conducted to retrieve relevant articles. Among the 105 retrieved articles, 25artideswere included in result analysis.RESULTS AND CONCLUSION: Currently, there are three kinds of methods to build biological pacemakers: gene transfection, celltransplantation and hormone cure. The research of biological pacemaker is still placed in the animal experimental step, and it hasa long way to go until the biological pacemakers can be used clinically, such as how to acquire safe and efficient gene vectors, thebest part for cell transplantation, how to adjust the pacing function and how to handle the immunity reject reaction, etc. We believeaccording to the developing of cell biology, cell electricity physiology, molecular biology and genetic engineering technology, theproblems that exist currently will gradually be settled and biologic pacemakers will become an effective way to treat cardiacconduction system disease.关键词
生物起搏器/基因转导/细胞移植/激素治疗/临床应用/综述文献分类
医药卫生
