南方医科大学学报2011，Vol.31Issue(11)：1956-封面3,2.DOI:44-1627/R.20111025.1052.006
阿德福韦酯致Fanconi综合征和低磷性骨软化症并进行性肌无力1例
Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B
李玲 1董光富 1张晓 1谢悦胜1
作者信息
- 1. 广东省人民医院风湿科/广东省医学科学院,广东广州510080
- 折叠
摘要
Abstract
Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B. The renal toxicity of adefovir dipivoxil is dose- and time-related, occurring often in patients with a daily dose over 30 mg and those with impaired renal function. We report a case of chronic hepatitis B with a history of taking adefovir dipivoxil at 10 mg/day for 4 years. The patient complained of lumbosacral and joint pain and had the diagnosis of ankylosing spondylitis (AS) or spondyloarthropathy in several hospitals before admission in our hospital. A diagnosis of acquired Fanconi syndrome and hypophosphatemia osteomalacia associated with progressive muscular weakness was made eventually. We reviewed the literature and found reports of only fewer than 10 similar cases. Clinical attention should be given to kidney damage induced by adefovir dipivoxil.关键词
阿德福韦酯/Fanconi综合征/低磷性骨软化症/低磷血症/代谢性酸中毒/肌无力/强直性脊柱炎Key words
adefovir dipivoxil/ fanconi syndrome/ hypophosphataemic osteomalacia/ hypophosphataemia/ metabolic acidosis/ muscular weakness/ ankylosing spondylitis分类
医药卫生引用本文复制引用
李玲,董光富,张晓,谢悦胜..阿德福韦酯致Fanconi综合征和低磷性骨软化症并进行性肌无力1例[J].南方医科大学学报,2011,31(11):1956-封面3,2.
