中国药业2011，Vol.20Issue(22)：32-33,2.
重组人5型腺病毒在体外对A549细胞的影响
Effect of Recombinant Human Adenovirus Type 5 to A549 in Vitro
蒋力 1侯兵 1崔珂钒 1闵家新1
作者信息
- 1. 中国人民解放军第三军医大学新桥医院胸外科,重庆,400037
- 折叠
摘要
Abstract
Objective To investigate the influence of recombinat human adenovirus type 5 on cell proliferation, cell cycle and apoptosis of A549 cells in vitro. Methods We examined the effect of recombinat human adenovirus type 5 on the cell biological characteristics of A549 cells in vitro with the methods of MTT, cell migration assay, flow oytometiy and TT'NET, assay. Results Hecomhinat human adenovinis Type 5 had a significant inhibition effect with lime - and concentration - dependence for A549 cells in vitro, at the same time, recombinat human adenovirus type 5 at a certain concentration could inhibit cell migration process significantly, and induced Ge/S phase arrest and cell apoptosis under the same conditions. Conclusion liecombinat human adenovims type 5 has an important role in the clinical therapy of tumor and wide prospect.关键词
重组人5型腺病毒/A549细胞/凋亡/细胞迁徙Key words
recombinal human adenovirus type 5/ A549 cells/ apoptosis/ cell migrations分类
医药卫生引用本文复制引用
蒋力,侯兵,崔珂钒,闵家新..重组人5型腺病毒在体外对A549细胞的影响[J].中国药业,2011,20(22):32-33,2.
