实用医学杂志2011，Vol.27Issue(22)：4043-4045,3.DOI:10.3969/j.issn.1006-5725.2011.22.023
转化生长因子-β1和斑块稳定性与动脉粥样硬化性脑梗死关系的研究
Correlation between TGF-β1 and stability of carotid plaque and atherosclerotic cerebral infarction
摘要
Abstract
Objective To explore the correlation between TGF-($1 and stability of carotid plaque and atherosclerotic cerebral infarction (ACI). Methods Seventy-eight patients with ACI (Group A), 46 patients with asymptomatic carotid atherosclerosis (Group B), and 28 controls (Group C) were collected for the study. The serum levels of TGF-pl were measured by ELISA, while the carotid plaque echogenicity was evaluated bilaterally by duplexdoppler ultrasound. Results The serum level of TGF-|31 in Group A was significantly lower than those in Group B and C (P < 0.001). Fatty plaque (60.9%) was the main type of plaque in Group A, while fibrous plaque (56.6%) was frequently seen in group B. Conclusion TGF-pl is associated with the stability of carotid plaque and plays a key role in the pathogenesis of ACI.关键词
脑梗死/转化生长因子-β1/颈动脉粥样硬化Key words
Brain infarction/ Transforming growth factor-pi/ Carotid arteriosclerosis引用本文复制引用
彭忠兴,甄毅锋,陈瑞芳,洪铭范,杨焰,刘爱群,蔡小燕..转化生长因子-β1和斑块稳定性与动脉粥样硬化性脑梗死关系的研究[J].实用医学杂志,2011,27(22):4043-4045,3.基金项目
广东省卫生厅医学科研基金资助项目(编号:A2010312) （编号:A2010312）
