实用医学杂志2011，Vol.27Issue(22)：4034-4036,3.DOI:10.3969/j.issn.1006-5725.2011.22.020
大鼠急性脊髓损伤后神经胶质酸性蛋白的表达意义
Expression of glial fibrillary acidic protein after acute spinal cord injury in rats
李宽新 1王维山 1史晨辉1
作者信息
- 1. 832000,石河子大学医学院一附院骨一科
- 折叠
摘要
Abstract
Objective To investigate the expression of glial fibrillary acidic protein (GFAP) and its effect on the recovery of hind limb function after spinal cord injury (SCI) in rats. Methods Thirty rats were randomly divided into blank control group (n = 5) and injury group (n = 25). Spinal cord was injured with Allen's weight dropping model, and each rat received contusion on its spinal cord at T9 with modified Allen's impactor. The motor function was evaluated by the Basso, Beattie & Bresnahanlocomotor rating scale (BBB scale). The expression of GFAP was measured by immunohistochemical staining and imaging analysis. Results Based on BBB scale, there was about 68% of selfrecovery rate of hind limb function of the injured rats. GFAP was expressed in every part of spinal cord in blank control group, and was increased with time in the injured area 1, 3, 5 d after spinal cord injury in injury group, then was decreased with time 5 d after injury, and was decreased to normal level 2 weeks after injury (P > 0.05). Conclusion There was a tendency of self-repairing after spinal cord injury. Reactive astrogliosis may play an important role in self-repairing and regeneration after spinal cord injury关键词
脊髓损伤/BBB评分/GFAPKey words
Spinal cord injury/ BBB scale/ GFAP引用本文复制引用
李宽新,王维山,史晨辉..大鼠急性脊髓损伤后神经胶质酸性蛋白的表达意义[J].实用医学杂志,2011,27(22):4034-4036,3.
