实用医学杂志2011，Vol.27Issue(22)：4046-4048,3.DOI:10.3969/j.issn.1006-5725.2011.22.024
低氧性肺动脉高压患者肺动脉收缩压与MMP-2、TIMP-1和炎性因子的相关性研究
Correlations between pulmonary artery systolic pressure and MMP-2, TIMP-1, inflammatory factors in patients with hypoxic pulmonary hypertension
摘要
Abstract
Objective To investigate the correlations between pulmonary artery systolic pressure (PASP) and MMP-2, TIMP-1, inflammatory factors in patients with hypoxic pulmonary hypertension (HPH), and evaluate the mechanism of HPH. Methods Levels of PASP, MMP-2, TIMP-1, TNF-a, IL-6, hs-CRP were measured in 52 patients with HPH and 50 healthy controls. Results Levels of MMP-2, TIMP-1, hs-CRP, TNF-a, and IL-6 in patients with HPH were higher than those in healthy controls (P < 0.05). Levels of PASP in patients with HPH were positively correlated with the levels of MMP-2, MMP-2/TIMP-1, hs-CRP, TNF-a, and IL-6. Multiple backward regression analysis showed that MMP-2, MMP-2/TIMP-1, hs-CRP, and TNF-a may be used to predict PASP. Conclusion MMPs system and inflammation factors may play important roles in the development of HPH.关键词
高血压,肺性/肺动脉收缩压/基质金属蛋白酶-2/基质金属蛋白酶抑制因子-1/炎症因子Key words
Hypertension, pulmonary/ Pulmonary artery systolic pressure/ Matrix metalloproteinase-2/ Tissue inhibitor of metalloproteinase-1/ Inflammation mediators引用本文复制引用
向光明,高宝安,陈世雄,官莉,阮玉姝,张婷婷,赵必君..低氧性肺动脉高压患者肺动脉收缩压与MMP-2、TIMP-1和炎性因子的相关性研究[J].实用医学杂志,2011,27(22):4046-4048,3.基金项目
湖北省卫生厅青年人才基金(编号:QJX2008-21) （编号:QJX2008-21）
