中国组织工程研究与临床康复2011，Vol.15Issue(47)：8813-8816,4.DOI:10.3969/j.issn.1673-8225.2011.47.018
负压吸附式止血敷贴的制备及其生物相容性
Preparation and biocompatibility of negative pressure adsorption hemostasis application
摘要
Abstract
BACKGROUND: Some hemostatic materials applied at present have many shortages, such as toxicity and high cost.OBJECTIVE: To study the biocompatibility of negative pressure adsorption hemostasis application in animals.METHODS: A strip-shaped incision was created in the liver and kidney, 1 cm in length and 0.5 cm in depth. Negative pressure adsorption hemostasis application was used on the wound area of six healthy pigs. General state of the healthy pigs was observed before and after the operation. Blood routine examination, liver and kidney function, body fluid immunology before and 14 days after the operation were detected. Histopathological changes at 14 days were observed.RESULTS AND CONCLUSION: There were no significant differences in blood biochemistry and immunology between the two groups (P > 0.05) and the histopathological results did not show any inflammatory reaction in incisions of liver and kidney tissues.There was no inflammation or fibrous tissue envelope. Negative pressure adsorption hemostasis application has good biocompatibility without any toxicity, reject reaction, immunological reaction and anaphylactic response in animals.关键词
止血敷贴/负压吸附/多孔止血淀粉/生物相容性/不良反应分类
医药卫生引用本文复制引用
李明洋,黄赤兵,范明齐,冯嘉瑜,张嘉希,高渝,陈益荣..负压吸附式止血敷贴的制备及其生物相容性[J].中国组织工程研究与临床康复,2011,15(47):8813-8816,4.基金项目
重庆市攻关课题(csci2007AC5046),课题名称:吸附式止血敷贴关键部件的研制. （csci2007AC5046）
