实用肝脏病杂志2011，Vol.14Issue(6)：407-409,3.DOI:10.3969/j.issn.1672-5069.2011.06.003
水飞蓟素对非酒精性脂肪性肝炎大鼠小肠组织抗氧化作用的实验研究
Anti-oxidant effects of silymarin on intestinal tissues in rats with non- alcoholic steatohepatitis
郭秀丽 1徐有青 1杨昭徐1
作者信息
- 1. 100050,北京市,首都医科大学附属北京天坛医院消化内科
- 折叠
摘要
Abstract
Objective To explore the anti-oxidant effects of silymarin on intestinal tissues in rats with non-alcoholic steatohepatitis.Methods Fifty Wistar rats were randomly divided into control, model and silymarin groups.The rats in control group were fed with normal diet.The rats in model group were fed with fat rich diet and saline by gastric lavage method to establish the model of NASH.The rats in silymarin group were fed with fat rich diet and silymarin by gastric lavage method.All rats in each group were observed for 12 weeks.Results The serum levels of TCTCALT and AST were higher in model group than those in control group.The serum levels of TCTCALT and AST were lower in silymarin group than those in model group (F=36.626~64.327,P＜0.0l); The activitives of SOD were lower in model group than in control group (83.29±10.32 U/mgprot vs.52.34±7.09 U/ mgprot) .The activitives of SOD in silymarin group were higher than those in model group; The changes of MDA were on the contrary (0.56±0.07 Nmol/mgprot vs.0.97±0.09 Nmol/mgprot,F=23.488 and 10.609, respectively,P＜0.05); The levels of ET in model group (0.316±0.020EU/ml)were higher than in silymarin grou p (0.279±0.022EU/ml). Conclusion Silymarin, an anti-oxidant drug, can protect the hepatocytes and the intestines in rats with NASH.关键词
非酒精性脂肪性肝炎/水飞蓟素/氧化应激Key words
Non-alcoholic steatohepatitis/ Silymarin/ Oxidative stress引用本文复制引用
郭秀丽,徐有青,杨昭徐..水飞蓟素对非酒精性脂肪性肝炎大鼠小肠组织抗氧化作用的实验研究[J].实用肝脏病杂志,2011,14(6):407-409,3.
