中国组织工程研究与临床康复2011，Vol.15Issue(47)：8887-8890,4.DOI:10.3969/j.issn.1673-8225.2011.47.037
药物控释载体材料的研究与应用
Application and progress in the materials for drug controlled release
王洪新 1陈晓明1
作者信息
- 1. 武汉理工大学生物材料与工程研究中心,湖北省武汉市,430070
- 折叠
摘要
Abstract
BACKGROUND: Polymer materials play an important role in drug controlled release system. But nano-inorganic materials are studied as a new drug and gene controlled delivery carrier and appears to be very promising, so more considered are paied attention to the design and research of drug controlled release carrier materials.OBJECTIVE: To summarize the applications and research progress of drug controlled release materials.METHODS: Database of CNKI and Elsevier SD (1999-01/2011-01) were retrieved to search the related articles about the materials for drug controlled release using the keywords of “polymer, mesoporous materials, inorganic silicon, calcium phosphate,controlled release” in Chinese and English. Finally, 25 articles were included in review analysis.RESULTS AND CONCLUSION: Drug controlled release carrier materials are widely drawn by their low dosage, long duration and good target effect. But there are still some deficiencies such as the drug inactivation and loss of biological activity after drug loading. The clinical application of drug controlled release carrier materials will be used more widely along with the development of composite carriers for drug delivery and transdermal drug delivery systems.关键词
药物控释材料/天然高分子/人工合成高分子/有序介孔材料/纳米无机材料分类
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王洪新,陈晓明..药物控释载体材料的研究与应用[J].中国组织工程研究与临床康复,2011,15(47):8887-8890,4.
