广东医学2011，Vol.32Issue(23)：3121-3123,3.
广西肝癌高危人群队列和高发家系样本数据库的建立
Construction of the specimen bank and epidemiological database of high-risk population of liver cancer in Guangxi
摘要
Abstract
Objective To establish the specimen bank and epidemiological database of high-risk population of liver cancer in Guangxi. Methods In the high-risk area of liver cancer, permanent residents at high incidence age were enrolled for the anti-cancer screening and epidemiological surveys. The HBsAg-positive subjects were chosen as high-risk population cohort of liver cancer, and were regularly followed-up and reviewed. In accordance with population-based tumor registry data and clinical epidemiological data, high incidence families and the matched control families were determined. The morning fasting peripheral venous blood from these persons was collected for assessment of chemical and biological indicators, such as HBsAg. B-ultrasonography was also performed. The serum, plasma and mononuclear cells were separated and preserved under-80℃. All the information was carried out by quality control and recorded to the database. Results Serum, plasma, mononuclear cells and the basic data from more than 30 000 cases had been collected. Blood specimens were properly preserved, and the data were dynamically managed by computer. Conclusion The specimen bank and epidemiological database offer a resource-sharing platform for further basic and clinical research on high incidence tumors in Guangxi region. Thus establishing the generic data management system should be a model for other cancer-related researches.关键词
肝癌/样本库/高发家系/高危人群队列Key words
liver cancer/specimen bank/high incidence family/high-risk population cohort引用本文复制引用
张春燕,黄天壬,余家华,张振权,利基林,邓伟,叶司原,周德南,何振芳..广西肝癌高危人群队列和高发家系样本数据库的建立[J].广东医学,2011,32(23):3121-3123,3.基金项目
国家自然科学基金资助项目(编号:81060173),卫生部和中国癌症基金会肝癌早诊早治示范基地项目(编号:2006009),广西自然科学基金资助项目(编号:2010GXNSFA013242),广西卫生厅重点资助项目(编号:重2010117) （编号:81060173）
