安徽中医学院学报2011，Vol.30Issue(6)：47-50,4.DOI:10.3969.j.issn.1000-2219.2011.06.016
生脉成骨胶囊对激素性股骨头坏死髋周间充质细胞增殖的影响
Effects of Shengmai Chenggu Capsules on Proliferation of Mesenchymal Stem Cells around Hip Joint in Rats with Steroid-Induced Avascular Necrosis of Femoral Head
摘要
Abstract
Objective To research the effects of Shengmai Chenggu Capsules (SCC), a traditional Chinese prescription, on the osteogenesis of mesenchymal stem cells and the mineralization nodus formation of osteoblasts of iliac bone and femur in rats with steroid-induced avascular necrosis of femoral head (SANFH). Methods Sixty SD male rats were randomly divided into 6 groups:normal control group,model group,SCC prevention group,Alendronate treated group,Danyu Gukang (a patent traditional Chinese medicine) treated group and SCC treated group. The effects of SCC on the osteogenesis of the proximal ilium and femur were observed by determining the proliferation of mesenchymal stem cells and the number of mineralization nodus.Results The transformation and proliferation levels of mesenchyma stem cells and the number of mineralization nodus in femur and iliac bone were significantly higher in SCC prevention group than those in the model group.Furthermore,the above-mentioned indicators in SCC prevention group were significantly higher than those in other treatment groups. Conclusion SCC can promote the proliferation of mesenchymal stem cells and the mineralization nodus formation of femur and iliac bone,which is in favor of the osteogenesis in SANFH rats.关键词
股骨头坏死/生脉成骨胶囊/间充质细胞/增殖/成骨Key words
femoral head necrosis/ Shengmai Chenggu Capsules/mesenchymal cells/proliferation/osteogenesis分类
医药卫生引用本文复制引用
李保林,熊平,庾伟中,贺华勇,叶勇光,王剑文..生脉成骨胶囊对激素性股骨头坏死髋周间充质细胞增殖的影响[J].安徽中医学院学报,2011,30(6):47-50,4.基金项目
广东省科技计划项目(93087) （93087）
广州市越秀区科技计划项目(2010-WS-001) （2010-WS-001）
