分析化学2011，Vol.39Issue(8)：1201-1207,7.DOI:10.3724/SP.J.1096.2011.01201
气相色谱-串联质谱法同时测定化妆品中的10种挥发性亚硝胺
Determination of 10 Volatile Nitrosamines in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry
摘要
Abstract
A comprehensive analytical method based on gas chromatography tandem mass spectrome-try has been developed for the determination of 10 volatile nitrosamines (N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodi-n-propylamine, N-nitrosomorpholine, N-nitrosopyrrolidine, N-nitrosopiperidine, N-nitrosodi-n-butylamine, N-nitrosodiphenylamine, N-nitrosodicyclohexylamine and N-nitrosodibenzylamine) in cosmetics. Various cosmetic samples, including cream, lotion, powder, shampoo and lipstick, were extracted with appropriate solvents under ultrasonication. The extract was centrifuged, and the upper solution was then cleaned up by an Oasis HLB solid phase extraction cartridge. Qualitative and quantitative analysis was carried out for the analytes under the MRM mode after the chromatographic separation on a DB-624 (30 m×0. 25 mm, 1. 40 μm) capillary column. The limits of quantitation (LOQs) for 10 volatile nitrosamines were 2. 5 -10 mg/kg. The mean recoveries at the three spiked levels were 85. 2% -102. 3%, with the relative standard devia-tions between 3. 1% and 9. 2%.关键词
固相萃取/气相色谱-串联质谱/化妆品/挥发性亚硝胺Key words
Solid phase extraction/ Gas chromatography-tandem mass spectrometry/ Cosmetics/ Volatile nitrosamines引用本文复制引用
马强,席海为,王超,白桦,席广成,苏宁,徐丽艳,王军兵..气相色谱-串联质谱法同时测定化妆品中的10种挥发性亚硝胺[J].分析化学,2011,39(8):1201-1207,7.基金项目
本文系质检公益性行业科研专项计划资助项目(No.200910267)、国家标准委员会计划资助项目(No.20090915-T-607)和中国检验检测疫科学研究院基本科研业务专项基金(No.2009JK016)资助 （No.200910267）
