中国实用妇科与产科杂志2011，Vol.27Issue(10)：767-770,4.
人雌激素硫酸基转移酶基因在雌激素依赖型子宫内膜腺癌组织中的表达及临床意义
Expression and significance of hEST gene in estrogen-dependent endometrial adenocarcinoma tissues
摘要
Abstract
Objective To research relationship between the occurrence and development of endometrial adenocarcinoma, to provide significant assistance to studies on etiology of endometrial adenocarcinoma. Methods Inspect the protein expression of hEST by Western-Blot test, inspect the expression of the mRNA of the hEST by RT-PCR, comparing the difference in different tissues. Results The content of hEST protein and mRNA expression in normal endometrial proliferation, secretory period and shrink endometrial tissue was significantly (P <0.01 ). The content of hEST protein and mRNA expression in normal endometrium was the high, and decreased inatypical hyperplasia and endometrial adenocarcinoma tissues. The difference among the three groups was very marked ( P < 0.01). In endometrial adenocarcinoma tissues with different clinical stage, pathological, muscular invasion and so on, the expression level of the mRNA and protein of hEST were of no difference ( P > 0. 05 ). In endometrial adenocarcinoma, hEST mRNA and protein in the ER-posi-tive was significantly higher than the ER-negative with significant differences (P < 0.01). Conclusions hEST may be related with the tumorigenesis of estrogen-dependent endometrial adenocarcinoma,but hEST wasn't index for endometrial adenocarcinoma.关键词
子宫内膜腺癌/基因/人雌激素硫酸基转移酶/雌激素代谢Key words
endometrial adenocarcinoma/ gene/ hEST/ metabolism of estrogen分类
医药卫生引用本文复制引用
王敏,张传英,史春雪,常爽..人雌激素硫酸基转移酶基因在雌激素依赖型子宫内膜腺癌组织中的表达及临床意义[J].中国实用妇科与产科杂志,2011,27(10):767-770,4.基金项目
辽宁省教育厅科学研究项目(20060962) （20060962）
