中国实用妇科与产科杂志2011，Vol.27Issue(10)：771-774,4.
IB-ⅡA期子宫颈癌患者贫血与盆腔淋巴结转移及预后的关系
Anemia in patients with FIGO Stage I B ~ Ⅱ A cervical cancer: association with pelvic lymph node metastases and poor overall survival
摘要
Abstract
Objective To investigate whether there is a correlation between anemia, other clinicopathologic variables, and survival in early cervical cancer patients treated surgically. Methods 454 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I B ~ H A cervical carcinoma and treated with surgery were retro-spectivly analysed. Anemia was defined in terms of hemoglobin concentration less than 1 lOg/L. The relationships among pre-treatment anemia presence, clinicopathologic features and prognosis of these patients were evaluated. Results The prevalence of anemia in our patients was 21. 8% ( n = 99). Anemia presence was significantly associated with FIGO stage flA(P= 0.001), tumor diameter >4cm (P< 0.001), lymph vascular space invasion (LVSI, P = 0.028) , positive parametrium invasion (P= 0.030) and pelvic lymph node metastasis (P < 0.001). The multivariate analysis revealed that anemia was one of the independent risk factors for predicting pelvic lymph-node metastasis. The 5-year overall survival (OS) for anemic and non-anemic patients were 72% and 88% respectively(/'< 0.001). Using the Cox regression analysis, anemia(P= 0.027) ^LVSI(P= 0.002)and pelvic lymph nodes metastasis(P < 0.001 )were significant and independent prognostic factors of OS in early cervical cancer patients treated with surgery. Conclusion Pre-treatment anemia is associated with pelvic lymph node metastasis and poor overall survival in patients with early stage cervical cancer.关键词
子宫颈癌/贫血/盆腔淋巴结/预后Key words
cervical cancer/ anemia/ pelvic lymph node/ prognosis分类
医药卫生引用本文复制引用
周瑜琪,李琎 ,吴小华..IB-ⅡA期子宫颈癌患者贫血与盆腔淋巴结转移及预后的关系[J].中国实用妇科与产科杂志,2011,27(10):771-774,4.基金项目
国家自然科学基金(编号:30672417) （编号:30672417）
