中国实用儿科杂志2011，Vol.26Issue(10)：748-751,4.
甲氨蝶呤诱发急性淋巴细胞白血病患儿急性脑病7例临床与影像学特点分析
Clinical and radiological features of methotrexate-induced acute encephalopathy in children with acute lymphoblastic leukemia
漆佩静 1王彬 1周翾 1吴敏媛1
作者信息
- 1. 首都医科大学附属北京儿童医院血液病中心,北京,100045
- 折叠
摘要
Abstract
Objective To investigate the clinical and radiological features of methotrexate (MTX) -induced acute encephalopathy in children with acute lymphoblastic leukemia (ALL). Methods We reviewed clinical and radiological dtta of this complication in childhood acute lymphoblastic leukemia treated from July 1, 2005 to August 31, 2009 in Beijing Children Hospital. Results Seven patients experienced acute encephalopathy within 3 ~ 10 days after receiving high-dose I.v. And/or intrathecal MTX. The signs and symptoms varied at presentation: hemiparesis,dysphasia,seizure, weakness and facial palsy. All patients recovered after 3 ~ 5 days. Acute enoephalopathy occurred associated with the dosage of MTX, the age of the patients and MTX metabolism. Four patients had restricted diffusion by diffusion-weighted image (DW1) in the deep white matter, esp. Centrum semiovale and corona radiate. Conclusion Acute MTX encephalopathy often manifests transient and focal motor function deficit. Restricted diffusion on DWI is a sensitive sign of acute MTX encephalopathy.关键词
甲氨蝶呤/白血病/儿童/脑病Key words
methotrexate/ leukemia/ child/ encephalopathy分类
医药卫生引用本文复制引用
漆佩静,王彬,周翾,吴敏媛..甲氨蝶呤诱发急性淋巴细胞白血病患儿急性脑病7例临床与影像学特点分析[J].中国实用儿科杂志,2011,26(10):748-751,4.
