癌症（英文版）2011，Vol.30Issue(10)：721-730,10.DOI:10.5732/cjc.011.10070
Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population
Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population
Chang-Hu Zhou 1Dong Wei 2Ze Yang 3Jian-Ye Wang 2Su-Yan Cao 1Xiao-Hong Shi 3Yao-Guang Zhang 2Ming Liu 3Xin Wang 2Jin Huang 3Yi-Ge Yang3
作者信息
- 1. The Fifth School of Clinical Medicine,Peking University,Beijing 100730,P.R.China
- 2. Department of Urology,Beijing Hospital,Ministry of Health,Beijing 100730,P.R.China
- 3. Beijing Institute of Geriatrics,Beijing Hospital,Ministry of Health,Beijing 100730,P.R.China
- 折叠
摘要
Abstract
In European populations,7 single nucleotide polymorphisms(SNPs) on chromosome 17q,3 SNPs on 17812,and 4 SNPs on 17824.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association study.In Japanese populations,the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale experiment.However,whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still unknown.Therefore,we conducted a case-control study in a northern Chinese population and tested 2 SNPs,rs4430796 and rs1859962,on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with sequencing.We analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients'lifestyles,onset ages,Gleason scores,PSA levels,and pathologic stages.We found a significant difference in the G allele of SNP rs1859962(P=0.035,OR=1.51,95% CI=1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls(P＞0.05).Neither of the SNPs was significantly associated with the onset age,Gleason score,PSA level,pathologic stage,or other clinical indicators of patients with prostate cancer(P＞0.05).Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population.关键词
Prostate cancer/ 17q/ single nucleotide polymorphisms(SNPs)/ association/risk geneKey words
Prostate cancer/ 17q/ single nucleotide polymorphisms(SNPs)/ association/risk gene引用本文复制引用
Chang-Hu Zhou,Dong Wei,Ze Yang,Jian-Ye Wang,Su-Yan Cao,Xiao-Hong Shi,Yao-Guang Zhang,Ming Liu,Xin Wang,Jin Huang,Yi-Ge Yang..Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population[J].癌症（英文版）,2011,30(10):721-730,10.
