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复合诱变选育9α-羟基青蒿素高转化率菌株

唐萍艳 刘吉华 余伯阳

南京师大学报(自然科学版)2011,Vol.34Issue(3):107-110,4.
南京师大学报(自然科学版)2011,Vol.34Issue(3):107-110,4.

复合诱变选育9α-羟基青蒿素高转化率菌株

Breeding of the High 9α-Artemisinin Transformation Ratio Strain by Compound Mutation

唐萍艳 1刘吉华 1余伯阳1

作者信息

  • 1. 中国药科大学中药复方实验室,江苏,南京,211198
  • 折叠

摘要

Abstract

To increase the 9α-hydroxy-artemisinin transformation ratio, fermentated Streptomyces griseus ATCC-13273 in the way of ultraviolet(UV) and microwave compound mutation, and bred it by medium which uses artemisinin as the only carbon source. It proved that it is an effective way to increase the ratio of Streptomyces griseus ATCC-13273 transforms artemisinin into 9α-hydtoxy-artemisinin by UV ray and microwave compound mutation, the yield of 9α-hydroxy-artemisi-nin is 50. 7% , which is almost twice higher than the initial strain's.

关键词

9α-羟基青蒿素/复合诱变/选育

Key words

9α-hydroxy-artemisirun/compound mutation/breeding

分类

生物科学

引用本文复制引用

唐萍艳,刘吉华,余伯阳..复合诱变选育9α-羟基青蒿素高转化率菌株[J].南京师大学报(自然科学版),2011,34(3):107-110,4.

基金项目

江苏省"六大人才高峰"资助项目. ()

南京师大学报(自然科学版)

OA北大核心CSCDCSTPCD

1001-4616

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