中国医科大学学报2011，Vol.40Issue(7)：608-610,625,4.DOI:21-1227/R.20110705.1002.016
小鼠肾集合管发育中的细胞凋亡与水通道蛋白2的表达
Expression of Aquaporin-2 and Cell Apoptosis in Collecting Ducts during Kidney Development of Mouse
摘要
Abstract
Abstract Objective To observe the expression of AQP-2 and cell apoptosis in collecting ducts of mice during development, and to discuss the relationship between AQP-2 and cell apoptosis. Methods Immunohistoche-mistry,electron microscope,TUNEL and stereology were used to detect the expression of AQP-2 and cell apoptosis in the collecting ducts of mice at E17 d,E18 d,Nl d,N7 d,N14 d,N21 d and N40 d. Results Cell apoptosis could be seen at N1 d in collecting ducts and reached the peak at N7 d. The expression of AQP-2 was weak at E17 d but strongest at N7 d,with the surface density reaching the maximum (0.044 1±0.001 8 μm-1) as well.From N21 d to N40 d, both cell apoptosis and expression of AQP-2 were unchanged. Conclusion The results suggest that AQP-2 has some effect on cell apoptosis and paly an important role in the development of collecting ducts.关键词
水通道蛋白2/细胞凋亡/集合管/发育/小鼠Key words
Key words aquaporin-2/ apoptosis/ collecting duct/ development/ mouse分类
医药卫生引用本文复制引用
田鹤,王旭,李晓明,郭敏..小鼠肾集合管发育中的细胞凋亡与水通道蛋白2的表达[J].中国医科大学学报,2011,40(7):608-610,625,4.基金项目
辽宁省教育厅高校科研计划(L20100269) （L20100269）
