郑州大学学报（医学版）2011，Vol.46Issue(5)：694-696,3.
重组纤维连接蛋白诱导自体CIK联合IFN-α治疗晚期肝癌疗效
Therapeutic effects of retronectin activated autologous CIK combined IFN-α on advanced hepatocellular carcinoma
摘要
Abstract
Aim:To determine the feasibility of retronectin actived auto-CIK combined with IFN-α hepatocellular carsinoma( HCC). Methods; CIK were generated from peripheral blood mononuclear cells ( PBMC) from 14 patients with advanced HCC induced by retronectin,CD3 monoclonal antibody,IL-2 ,and IFN-γ. CIK was transfused intravenously ever-y week for at least 4 times and IFN-α were administrated three times per week. The cytokine secretion profile was analyzed by BD?-CBA Human Thl/Th2 kit before and after treatment. Results:The median number of transferred cells per patient was 25. 6×109(21.6×109 ~ 31. 8×109) , and the toxicity profile were tolerable. After CIK and IFN-a were administrated , the absolute median count of lymphocytes, CD3+ , CD3+ CD8+ and CD3+ CD56+ cells significantly increased in patient' s peripheral blood. One patient had partial response ( PR) and four patients had stabilization of disease (SD) . The downtrend of AFP level was observed in the PR and two SD patients. In the clinical benefit patients, an increased production of IFN-γ and TNF-α in the serum were observed after treatment(t = 12. 644,17. 169,P＜0. 001 ). Conclusion: Adoptive immunotherapy with retronectin induced CIK cells combined with IFN-a is a safe and effective therapy.关键词
肝癌/细胞因子诱导的杀伤细胞/免疫功能/重组纤维连接蛋白Key words
hepatocellular carcinoma/ CIK/ immune function/ retronectin分类
医药卫生引用本文复制引用
徐本玲,袁龙,高全立,范瑞华,张成娟,宋永平..重组纤维连接蛋白诱导自体CIK联合IFN-α治疗晚期肝癌疗效[J].郑州大学学报（医学版）,2011,46(5):694-696,3.基金项目
河南省医学科技攻关计划基金资助项目 201001013 （）
