中国卒中杂志2011，Vol.6Issue(11)：915-921,7.
氯吡格雷、华法林及他汀类药物治疗缺血性卒中的遗传药理学研究
Pharmacogenetics Study of Clopidogrel, Warfarin and Statins in Ischemic Stroke Treatment
摘要
Abstract
Anti-platelet aggregation, coagulation and lipid regulation are the important measures of clinical treatment and prevention of ischemic stroke(IS). Clopidogrel, warfarin and statins are the commonly used therapy. However, genetic factors that lead to drug metabolizing enzymes, transporters and targets of drug response associated protein for activity individual differences, thus affecting the clinical drug efficacy and toxicity. In this review, we discuss the pharmacogenetics of clopidogrel, warfarin and statins of IS therapy, and analyze the gene polymorphism which affecting the drug efficacy and toxicity to facilitate the individualized treatment and prevention of IS.关键词
脑梗死/遗传药理学/多态现象,遗传/氯吡格雷/华法林/他汀类药物Key words
Brain infarction/ Pharmacogenetics/ Polymorphism, genetic/ Clopidogrel/Warfarin/ Statins引用本文复制引用
高一鹭,张拥波,李继梅..氯吡格雷、华法林及他汀类药物治疗缺血性卒中的遗传药理学研究[J].中国卒中杂志,2011,6(11):915-921,7.基金项目
北京市卫生系统高层次卫生技术人才培养计划项目(2009-03-07) （2009-03-07）
