中国当代儿科杂志2011，Vol.13Issue(11)：855-858,4.
促红细胞生成素治疗新生儿缺氧缺血性脑病疗效观察
Therapeutic effects of erythropoietin on hypoxic-ischemic encephalopathy in neonates
王英娟 1潘凯丽 2赵晓莉 2强欢 2成胜权2
作者信息
- 1. 榆林市第一医院儿科,陕西榆林719000
- 2. 解放军第四军医大学西京医院儿科,陕西西安710032
- 折叠
摘要
Abstract
Objective To study the efficacy of erythropoietinin (EPO) in the treatment of moderate or severe hypoxic-ischemic encephalopathy ( HIE) in neonates. Methods Seventy neonates with moderate or severe HIE were randomly assigned to two groups: EPO treatment and control (n = 35 each). The EPO treatment group included 22 cases of moderate HIE and 13 cases of severe HIE. The control group included 24 cases of moderate HIE and 11 cases of severe HIE. Thirty-five healthy full-term infants served as normal group. The control group received a conventional treatment. Beside the conventional treatment, the EPO treatment group was intravenously injected with EPO of 200 IU/kg · D, 3 times weekly. Routine blood test was performed every 6 days. EPO dose was adjusted based on the results of the routine blood test. The course of EPO treatment was 2 to 4 weeks. Neonatal Behavioral Neurological Assessment ( NBNA) was performed at age of 28 days. The infant development test of Child Development Centre of China ( CUCC) was performed at ages of 3 months and 6 months. Results The percentage of normal NBNA scores in the EPO treatment group was significantly higher than that in the control group at age of 28 days (P < 0. 05 ) , but was significantly lower than that in the normal group (P<0.01). The CDCC test including physical development index (PDI) and physical development index (MDI) showed the percentage of normal results in the EPO treatment group was significantly higher than in the control group at age of 3 months (P<0.05) , but was significantly lower than in the normal group (P<0.01). The CDCC test including PDI and MDI showed that the percentage of normal results in the EPO treatment group was significantly higher than in the control group at age of 6 months. The MDI test results in the EPO treatment group were not significantly different from those in the normal group at age of 6 months, but the percentage of normal results in the PDI test in the EPO treatment group was still significantly lower than that in the normal group ( P < 0. 05 ). Conclusions EPO treatment has neuroprotective effects against moderate or severe HIE and improves long-term behavioral neurological developments in neonates.关键词
促红细胞生成素/缺氧缺血性脑病/新生儿Key words
Erythropoietin/ Hypoxic-ischemic encephlopathy/ Neonate分类
医药卫生引用本文复制引用
王英娟,潘凯丽,赵晓莉,强欢,成胜权..促红细胞生成素治疗新生儿缺氧缺血性脑病疗效观察[J].中国当代儿科杂志,2011,13(11):855-858,4.
