中国当代儿科杂志2011，Vol.13Issue(11)：863-866,4.
儿童急性髓系白血病FLT3突变临床分析:单中心研究
FLT3 mutations in children with acute myeloid leukemia: a single center study
摘要
Abstract
Objective To study the clinical significance of FMS-like tyrosine kinase 3 ( FLT3 ) mutations including internal tandem duplication (ITD) mutation and point mutation of tyrosine kinase domain (TKD) in children with acute myeloid leukemia (AML). Methods Bone marrow samples from 116 children with newly-diagnosed AML were obtained. Gene mutations of FLT3/ITD and FLT3/TKD were detected by RT-PCR. The relationship of FLT3 gene mutations with the clinical characteristics and the therapeutic efficacy was observed. Results FLT3/ITD and FLT3/TKD mutations were detected in 9 cases (7.8% ) and 13 cases (11. 2% ) respectively out of the 116 children. FLT3/ITD mutations were observed in 3 cases of AML-M3 (3/9; 33. 3% ) and in 3 cases of AML-M5 (3/9; 33. 3% ). FLT3/TKD mutations were the most common in AML-M3 patients (10/13; 76.9% ). The patients with FLT3/1TD mutations had a significantly higher peripheral WBC count and marrow blast percentage compared with the patients without FLT3/ITD mutations at diagnosis (P<0. 01). The 3-year overall survival rate in patients with FLT3/ITD mutations was significantly lower than that in patients without FLT3/ITD mutations (38.9% vs 64.3% ; P <0.05). Conclusions FLT3/TKD mutations are common in children with AML-M3. The AML children with FLT3/ITD mutations present a high peripheral WBC count and a high marrow blast percentage at diagnosis and have an unfavorable outcome.关键词
急性髓系白血病/FLT3/基因突变/儿童Key words
Acute myeloid leukemia/ FLT3/ Gene mutation/ Child分类
医药卫生引用本文复制引用
阮敏,竺晓凡,王雅琴,张丽,刘天峰,刘芳,刘晓明,张家源,邹尧,陈玉梅..儿童急性髓系白血病FLT3突变临床分析:单中心研究[J].中国当代儿科杂志,2011,13(11):863-866,4.基金项目
天津市科技计划项目(编号:092CZDSF03800). （编号:092CZDSF03800）
