中国当代儿科杂志2011，Vol.13Issue(11)：873-877,5.
氯雷他定治疗儿童哮喘的疗效与安全性评价
Evaluation of efficacv and safety of loratadine in the treatment of childhood asthma
古丽巴哈·买买提 1阿布来提·阿布都哈尔 1徐佩茹1
作者信息
- 1. 新疆医科大学第一附属医院儿科,新疆 乌鲁木齐830054
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of loratadine, a new generation of antihistaminics, in the treatment of childhood asthma. Methods The papers related to loratadine treatment for childhood asthma were searched in the database of PubMed, MEDL1NE, EMBASE, Cochrance, CNKI and CBMdisc (January 1990 to December 2010) electronically and manually. According to the Coehrane reviewer's handbook, the quality of the enrolled papers was assessed and a systematic review was performed. Results A total of 179 papers were obtained. Eleven randomized controlled trials met the criteria and were included in this study. The 11 trials included 317 children with asthma; 159 cases in the loratadine treatment group and 158 cases in the control group. All included studies belonged to the B class according to the quality evaluation criteria. Meta analysis showed that the clinical symptoms were improved more, the forced expiratory volume in 1 second (FEV1) 4 and 8 weeks posttreatment and the peak expiratory flow rate ( PEFR) 8 weeks posttreatment were higher in the loratadine treatment group than in the control group. The treatment-related adverse effects, fatigue, tachycardia and palpitation, occurred less in the loratadine treatment group compared with the control group. Conclusions Loratadine is safe and effective for the treatment of childhood asthma.关键词
氯雷他定/疗效/安全性/Meta分析/儿童Key words
Loratadine/ Efficacy/ Safety/ Meta analysis/ Child分类
医药卫生引用本文复制引用
古丽巴哈·买买提,阿布来提·阿布都哈尔,徐佩茹..氯雷他定治疗儿童哮喘的疗效与安全性评价[J].中国当代儿科杂志,2011,13(11):873-877,5.
