新医学2011，Vol.42Issue(9)：571-573,3.DOI:10.3969/g.issn.0253-9802.2011.09.005
白花蛇舌草总黄酮对鼻咽癌细胞株CNE1增殖和凋亡的影响
Effects of the total flavones of oldenlandia diffusa willd on proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE1
摘要
Abstract
Objective: To investigate the effects of the total flavones of oldenlandia diffusa willd (FOD) on the proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE1. Methods; CNE1 cells were treated with a series of doses of FOD for 24 h or 48 h. The cellular growth inhibitory potency and cellular apoptosis rate were assessed by CCK-8 assay and Annexin V-FITC apoptotic detection assay, respectively. Results; FOD inhibited proliferation of CNE1 cells in a dose-dependent and time-dependent manner. Icjq of 24 h and 48 h were (27. 0 ± 2.5) mg/L and (12. 1 ±1.3) mg/L, respectively. Furthermore, FOD induced apoptosis of CNE1 cells in a dose-dependent and time-dependent manner. Conclusion; FOD inhibits the proliferation of nasopharyngeal carcinoma cell line CNE1, which is suggested to be involved in the induction of apoptosis.关键词
白花蛇舌草总黄酮/鼻咽癌/增殖抑制/凋亡Key words
Flavones of oldenlandia diffusa willd/ Nasopharyngeal carcinoma/ Inhibition of proliferation/ Apoptosis引用本文复制引用
邓雪清,刘汝青,肖勇梅,苏晓梅,魏青..白花蛇舌草总黄酮对鼻咽癌细胞株CNE1增殖和凋亡的影响[J].新医学,2011,42(9):571-573,3.基金项目
广东省中医药局科研课题(2008085) （2008085）
