摘要
Abstract
Objective To enhance the understanding of drug-induced liver injury by investigating the causes and clinical features of drug-induced liver injury cases in old people.Methods Eightsix drug-induced liver injury cases in old people admitted to our hospital from 2004-2010 were retrospectively analyzed and evaluated by using Maria's diagnostic scale.Results The four predominant etiological drugs were antibiotics ( 19 cases,22％ ),antitumor drugs ( 17 cases,19.8％ ),traditional Chinese herbs ( 16 cases,18.6％ ) and cardiovascular drugs ( 14 cases,16.3％ ),followed by neurologists medicines ( 4％ ) and antipyretic analgesics ( 4％ ).Other drugs included glucose-lowing drugs,hyperthyroidism drugs and immunosuppressive agents,each of them accounted for 2.3％ of the all cases.1.2％cases attributed to male hormone drugs and the causative drugs could not be clarified in 8 cases ( 5.8％ ).For clinical classification,49 cases ( 57％ ) were hepatocellular type,25 cases ( 29％ ) were cholestasis type,and 12 cases ( 14％ ) were mixed type.Conclusions Antibiotics,antitumor drugs,traditional Chinese herbs and cardiovascular drugs are the common drugs cause drug-induced liver injury among old people,doctors should be discreet and closely monitor the liver function when using these drugs.关键词
老年人/肝病/药物性/病因Key words
Old people/Liver injury/Drug-induced/Etiology
