实用临床医药杂志2011，Vol.15Issue(17)：46-48,3.
蛋白酶体抑制剂MG132对Caov-3细胞中NF-κB、CycLinD1表达的影响
The expression of NF-κB、CyclinD1 in Caov-3 cells after using proteasome inhibitor MG132
马忠平 1顾光华 1贾玉芳1
作者信息
- 1. 江苏省溧阳市人民医院妇产科,江苏溧阳,213300
- 折叠
摘要
Abstract
Objective To study the expression of NF-κB and CyclinDl in human ovarian cancer Caov-3 cells after using proteasome inhibitor MG132. Methods Cell culture and immuno histochemical assessment were performed for alterations in expression of NF - κB and CyclinD1. Re sults The expression level of NF - κB and CyclinDl decreased in Caov - 3 cells after being treated with MG132 for 24 hours. The differences were statistically significant (P<0.01). Conclusion MG132 could significantly induce the apoptosis of Caov - 3 cells. The part of anti - tumor mecha nism of MG132 suppresses tumor growth and induces apoptosis by inhibiting expression of NF-κB and CyclinD1.关键词
MG132/Caov-3/细胞培养/免疫组化/NF-κB/CycLinD1Key words
MG132/ Caov-3/ cell culture/ immunohistochemistry/ NF~κB/ CyclinDl分类
医药卫生引用本文复制引用
马忠平,顾光华,贾玉芳..蛋白酶体抑制剂MG132对Caov-3细胞中NF-κB、CycLinD1表达的影响[J].实用临床医药杂志,2011,15(17):46-48,3.
