南方医科大学学报2011，Vol.31Issue(11)：1895-1899,5.DOI:44-1627/R.20111025.1126.010
一种预测人工晶状体植入术后前房深度的新方法
A new method for predicting anterior chamber depth in intraocular lens implantation
摘要
Abstract
Objective To explore the mechanism underlying the therapeutic effect of Bushen Huoxue Decoction (BHD), a traditional Chinese medicinal preparation, on dopamine D2 receptor (DRD2) in the brain of rat models of Parkinson's disease (PD). Methods A total of 120 SD rats were randomized into normal control group, saline model group and BHD-treated group. In the latter two groups, PD rat models were established by direct injection of 6-OHDA to destruct the substantia nigra compact part (SNC) with corresponding treatments. The behavioral changes of the rats were observed. Radioimmunoassay was employed to determine the changes in the equilibrium dissociation constant (Kd) and maximal binding capacity (Bmax) of DRD2, and immunohistochemistry was used to observe the number of the DRD2-positive cells in the brain of the rats. Results BHD can markedly improve the behavioral abnormalities of PD model rats. Compared with those in the saline model group, the Bmax of DRD2 in the damaged hemisphere increased while the Kd of BHD decreased significantly after BHD treatment (P<0.01). The number of DRD2-positive cells in BHD-treated group was significantly higher than that in the model group (80.9 ±13.59 vs 11.15 ±6.78, P<0.01), but showed no significant difference from that in the normal control group (P>0.05). Conclusion BHD can improve the behavioral abnormalities and increase the cerebral expression and affinity of DRD2 in PD rat models.关键词
个性化人眼模型/对比敏感度函数/前房深度Key words
Parkinson's disease/ Bushen Huoxue Decoction/ dopamine D2 receptor分类
医药卫生引用本文复制引用
宋文晓,卢产文,刘致滨,杨晶娟,朱懿恒..一种预测人工晶状体植入术后前房深度的新方法[J].南方医科大学学报,2011,31(11):1895-1899,5.基金项目
广东省教育部产学结合重点项目(2010A090200003) （2010A090200003）
