国际医药卫生导报2011，Vol.17Issue(21)：2610-2613,4.DOI:10.3760/cma.j.issn.1007-1245.2011.21.008
急性呼吸困难病因分布和N末端B型利钠肽原对病因诊断的作用
Etiology of acute dyspnea and the role of N-terminal pro-B-type natriuretic peptide in etiologic diagnosis
李道海 1张远新 1梁子敬 1谢玉宝 1林锦潮1
作者信息
- 1. 广州医学院第一附属医院急诊科,510120广州
- 折叠
摘要
Abstract
Objective To investigate the causes of acute dyspnea and the clinical value of Nterminal pro-B-type natriuretic peptide ( NT-proBNP ) in identification of the early etiologies of acute dyspnea.Methods 290 patients presenting with acute wheezing or dyspnea during the period of Juanary 2010 to December 2010 were recruited.The etiologic diagnosis was made based on disease history,physical examination,lab tests,and responses to therapies.The causes of acute dyspnea were statistically analyzed and the patients were assigned to acute heart failure ( AHF ) group and non-heart failure ( NHF )group.Plasma NT-proBNP levels were compared between the two groups.Besults The four common causes of acute dyspnea were acute exacerbation of chronic obstructive pulmonary disease ( AECOPD )(n=110,37.9％),AHF (n=85,29.3％),acute asthma (n=36,12.4％),andpneumothorax (n =26,9.0％ ).NT-proBNP levels were markedly higher in AHF group than in NHF group ( P ＜ 0.01 ).As the cutoff value of plasma NT-proBNP was =1500 pg/ml,the sensitivity,specificity,and positive predictive value for diagnosing AHF were 91.8％,95.1％,and 88.6％.Conclusions The most frequent causes of acute dyspnea were AECOPD,AHF,acute asthma,and pneumothorax.Plasma NT-proBNP level is of importance in the primary screening of the causes of acute heart failure and the differentiation of cardiogenic from non-cardiogenic dyspnea.关键词
呼吸困难/N末端B型利钠肽原/心力衰竭Key words
Dyspnea/NT-proBNP/Heart failure引用本文复制引用
李道海,张远新,梁子敬,谢玉宝,林锦潮..急性呼吸困难病因分布和N末端B型利钠肽原对病因诊断的作用[J].国际医药卫生导报,2011,17(21):2610-2613,4.
