实用临床医药杂志2011，Vol.15Issue(17)：119-120,125,3.
沙利度胺口服联合5-FU和顺铂腹腔灌注治疗恶性腹水
Thalidomide combined with 5-FU Cisplatin in the treatment of malignant ascites
李亚星 1孙根林1
作者信息
- 1. 江苏泰州市第四人民医院肿瘤内科,江苏泰州,225300
- 折叠
摘要
Abstract
Objective To observe effect of Thalidomide in the treatment of malignant as cites and its possible mechanism. Methods Twenty patients with gastric cancer, 10 cases with rec tal cancer, 10 cases of ovarian cancer were confirmed with malignant ascites by ascites cytology cas es. In the control group, Cisplatin 60 mg, 5 - FU 500 mg, together with 250 mL normal saline were perfused intraperiton. But in the experimental group, oral Salle polyamine 8 mg/(kg·d) was added one night on the basis of the intraperitoneal infusion. Ascites was collected to determine con centrations of VEGF, MMP - 9, and TNF- a in ascites by EL1SA. Results Compared with the control group, TNF- a, VEGF and MMP - 9 in ascites of the experimental group were decreased. P values were less than 0.01, 0.05 and 0.05. CR and NC had no significant difference (P>0.05) in the two groups. PR differed from PD (P<0.05), CR + PR + NC were different (P<0.05). Conclusion Thalidomide inhibits TNF - a expression and thus inhibits the expression of VEGF and MMPs, and eventually inhibits the formation of ascites.关键词
沙利度胺/5-FU/顺铂/肿瘤坏死因子-a/血管内皮细胞生长因子/基质金属蛋白酶-9/腹水Key words
Thalidomide/ 5-FU/ Cisplatin/ tumor necrosis factor-a/ vascular endothelial growth factor/ matrix metalloproteinase -9/ ascites分类
医药卫生引用本文复制引用
李亚星,孙根林..沙利度胺口服联合5-FU和顺铂腹腔灌注治疗恶性腹水[J].实用临床医药杂志,2011,15(17):119-120,125,3.
