首页|期刊导航|中华医学杂志（英文版）|Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat
中华医学杂志（英文版）2011，Vol.124Issue(22)：3768-3772,5.DOI:10.3760/cma.j.issn.0366-6999.2011.22.030
Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat
Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat
摘要
Abstract
Background Platelet P-selectin plays an important role in inflammation and contributes to thrombosis and hemostasis.Fibrinogen may take part in inflammation,thrombosis,and hemostasis via enhancement of platelet P-selectin expression.This study aimed to discover the correlation between them in atherosclerosis model of Sprague Dawley (SD) rat.Methods Diet-induced atherosclerosis SD rats were adopted as experimental models.The blood from the common abdominal aorta of the rats was obtained to measure the biochemical characteristics and for the check of flow cytometry.Then the aortas were separated carefully,taken out,put into 10％ (w/v) neutral formalin for later use.Then fibrinogen and P-selectin expression were detected by flow cytometry and immunohistochemistry.Results SD rats were induced to atherosclerosis model by high fat diet and vitamin D2 injected.It was discovered that the binding of fibrinogen and the expression of P-selectin on the platelet increase in atherosclerosis model (Group H)than in that in the control group (Group Z),there were closely interrelated.High levels of fibrinogen and P-selectin express on the artery of atherosclerosis rat model.Conclusions Fibrinogen and P-selectin are concerned with atherosclerosis.Fibrinogen can interact with P-selectin in order to contribute to the development of atherosclerosis,high levels of fibrinogen and P-selectin can be regarded as risk factors for markers of atherosclerosis.关键词
fibrinogen/P-selectin/atherosclerosisKey words
fibrinogen/P-selectin/atherosclerosis引用本文复制引用
ZHOU Bi-rong,PAN Ying,ZHAI Zhi-min..Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat[J].中华医学杂志（英文版）,2011,124(22):3768-3772,5.基金项目
This work was supported by the grants from the Doctoral Fund of Ministry of Education of China (No.20103420110001),the Intercollegiate Key Project of Nature Science of Anhui Province (No.KJ2011A158),the Youth Research Program of Anhui Provincial Health Department (No.09B 106).Conflict of interest:None. （No.20103420110001）
