基础医学与临床2011，Vol.31Issue(11)：1261-1266,6.
骨形态发生蛋白-7基因变异与新疆维吾尔族老年人原发性高血压相关
The genetic variations of the bone morphogenetic protein 7 gene is associated with essential hypertension in Xinjiang old uygur population
摘要
Abstract
Objective To analyze the association between the genetic variations of functional region in bone mor-phogenetic protein (BMP7)gene and hypertension in Chinese Uygur individuals. Methods The all exons, segmen-tal introns and the promoter regions of BMP7 gene were sequenced in 48 Uygur Chinese. Representative variations were selected according to the minor allele frequency (MAF) and linkage disequilibrium and genotyped using the TaqMan polymerase chain reaction method in 1446 Uygur Chinese and a case-control study was conducted to test the association between genetic variations of BMP7 gene and hypertension. Results 5 novel and 8 known variations in the BMP7 gene were identified. All genotype distributions were tested for deviations from Hardy-Weinberg equilibrium (P >0. 05). There were significant differences of genotype distribution of rsl7480735 between hypertension and control groups(P<0. 05). And the means of blood pressure in individuals with GA + A A were significantly higher than in individuals with GG genotypes of rs17480735 in population with age≥50 years (P<0. 05). The logistic regression analysis showed that AA genotype of rsl7480735 variation might be a hypertensive risk factor in individuals with age ≥50years (P <0. 05) after affect factors(age, gender, BMI, drinking and smoking) were adjusted. Conclusion The present study suggests rsl7480735 polymorphism in the BMP7 gene may be associated with Hypertension in Uygur individuals with age ≥50 years.关键词
骨形态发生蛋白-7/基因多态性/高血压/新疆维吾尔族Key words
BMP7(bone morphogenetic protein 7) / polymorphism/ hypertension/ uygur分类
医药卫生引用本文复制引用
严治涛,李南方,郭艳英,姚晓光,王红梅..骨形态发生蛋白-7基因变异与新疆维吾尔族老年人原发性高血压相关[J].基础医学与临床,2011,31(11):1261-1266,6.基金项目
新疆维吾尔自治区高技术研究发展计划项目(201010107) （201010107）
